Articles

Liver transplantation for non-resectable colorectal liver metastases at a single centre in South Africa: A report of the ethics and regulatory approval process

Harriet Rosanne Etheredge, Jean Botha, Peter Cleaton-Jones

Abstract


Non-resectable colorectal liver metastases (CLMs) are generally considered an absolute contraindication for liver transplantation. However, a 2013 Norwegian study transplanted livers in 21 patients with CLMs and reported excellent outcomes. The current article reports on the deliberations of the Wits Human Research Ethics Committee (Medical), which resulted in approval of the first liver transplant for a patient with CLMs in South Africa (SA). Factors considered included the scarcity of donor organs in SA, weighing the best interests of different groups of patients and the requirement for extensive and careful information provision. Originally under the auspices of Section 37 of the World Medical Association Declaration of Helsinki (2013), the protocol has now been formalised as a research project.


Authors' affiliations

Harriet Rosanne Etheredge, Wits Donald Gordon Medical Centre

Jean Botha, Transplant Unit, Wits Donald Gordon Medical Centre

Peter Cleaton-Jones, Steve Biko Centre for Bioethics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg.

Full Text

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Keywords

Ethics, research, liver tranplant, colorectal cancer, non-resectable colorectal liver metastases

Cite this article

South African Journal of Bioethics and Law 2017;10(1):5-7. DOI:10.7196/sajbl.534

Article History

Date submitted: 2017-03-03
Date published: 2017-07-03

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