Estrogen is not only responsible for reproduction, but it also has a role in bone health, skin health, and cardiovascular health. However, estrogen also has a dark side because it is linked to cancer, dementia, strokes and pain.  Many women who have pain are also experiencing changes of the estrogen level--menopause. During menopause, estrogen levels fall along with progesterone and testosterone. As estrogen levels decline, thyroid levels will follow because estrogen effects Power of Hormones production. See how everything is connected? So, how does estrogen connect to chronic pain? Well, artificially elevated levels of estrogen like found with hormone replacement therapy and oral contraception are strongly linked to joint pain. Women who use these hormone products are more likely to experience spinal pain for example. Estrogen has also been linked to arthritis. Using estrogen is like adding fuel to the painful fire. Estrogen is not a no-risk fountain of youth. (Please also see the article about the link between brain shrinkage and hormone replacement therapy on the Alzheimer site

https://www.youtube.com/watch?v=KY6vy2UMZ1o