Leptin is a hormone that regulates your appetite and the percentage of body fat in your body. It acts as a "lipostat," that is, when the amount of fat stored in adipocytes increases, leptin is released into the bloodstream, informing the hypothalamus and endocrine mechanisms being activated to reduce appetite. With the discovery of leptin in 1994, research began on the hormonal mechanisms involved in appetite regulation, food consumption, storage in adipose tissue, and the development of insulin resistance.Leptoconnect Supplement Reviews